› 3gkz

X-ray diffraction
1.9Å resolution

Crystal structures of a therapeutic single chain antibody in complex methamphetamine

Released:
DOI: 10.2210/pdb3gkz/pdb
PDB 3gkz coloured by chain and viewed from the front.
PDB 3gkz coloured by chain and viewed from the side.
PDB 3gkz coloured by chain and viewed from the top.
Source organism: Mus musculus
Primary publication:
Crystal structures of a therapeutic single chain antibody in complex with two drugs of abuse-Methamphetamine and 3,4-methylenedioxymethamphetamine.
Celikel R, Peterson EC, Owens SM, Varughese KI
Protein Sci 18 2336-45 (2009)
PMID: 19760665

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
anti-methamphetamine single chain Fv Chain: A
Molecule details ›
Chain: A
Length: 257 amino acids
Theoretical weight: 27.79 KDa
Source organism: Mus musculus
Expression system: Komagataella pastoris
Structure domains: Immunoglobulins

Ligands and Environments

1 bound ligand:
Ligand B40 1 x B40
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL9-1
Spacegroup: P21
Unit cell:
a: 34.338Å b: 65.265Å c: 48.513Å
α: 90° β: 98.75° γ: 90°
R-values:
R R work R free
0.21 0.21 0.235
Expression system: Komagataella pastoris

Quick links

Citations

2 review citations

Customizing monoclonal antibodies for the treatment of methamphetamine abuse: current and future applications.
Peterson et al. (2014)
1 more

5 mentions without citation

Crystal structures of a therapeutic single chain antibody in complex with two drugs of abuse-Methamphetamine and 3,4-methylenedioxymethamphetamine.
Celikel et al. (2009)
4 more