› › Structure analysis

Human dihydrofolate reductase Q35K mutant inhibitor complex

X-ray diffraction
1.53Å resolution
PDB entry 3gi2 coloured by chain, front view.
PDB entry 3gi2 coloured by chain, side view.
PDB entry 3gi2 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

Quick links

Assemblies

Assembly 1 (preferred)
Download    3D Visualisation
Assembly Name: Dihydrofolate reductase
hide full assembly name
Multimeric state: monomeric
Accessible surface area: 9510.48 Å2
Buried surface area: 1204.21 Å2
Dissociation area: 602.11 Å2
Dissociation energy (ΔGdiss): 8.2 kcal/mol
Dissociation entropy (TΔSdiss): 6.51 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-132447

Macromolecules

Dihydrofolate reductase
Chain: A
Length: 187 amino acids
Theoretical weight: 21.48 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P00374 (Residues: 1-187; Coverage: 100%)
Gene name: DHFR
Pfam: Dihydrofolate reductase
InterPro:
CATH: Dihydrofolate Reductase, subunit A
Dihydrofolate reductase in PDB entry 3gi2, assembly 1, front view.
Dihydrofolate reductase in PDB entry 3gi2, assembly 1, side view.
Dihydrofolate reductase in PDB entry 3gi2, assembly 1, top view.
Molecule details ›

Search similar proteins

Quick links