› 3ggw

X-ray diffraction
1.7Å resolution

Crystal Structure of FAB F22-4 in complex with a Carbohydrate-mimetic peptide

Released:
DOI: 10.2210/pdb3ggw/pdb
PDB entry 3ggw coloured by chain, front view.
PDB entry 3ggw coloured by chain, side view.
PDB entry 3ggw coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Structural mimicry of O-antigen by a peptide revealed in a complex with an antibody raised against Shigella flexneri serotype 2a.
Theillet FX, Saul FA, Vulliez-Le Normand B, Hoos S, Felici F, Weintraub A, Mulard LA, Phalipon A, Delepierre M, Bentley GA
J Mol Biol 388 839-50 (2009)
PMID: 19328810

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-234053 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
FAB F22-4 LIGHT CHAIN Chains: A, C
Molecule details ›
Chains: A, C
Length: 219 amino acids
Theoretical weight: 24.14 KDa
Source organism: Mus musculus
Structure domains: Immunoglobulins
FAB F22-4 HEAVY CHAIN Chains: B, D
Molecule details ›
Chains: B, D
Length: 217 amino acids
Theoretical weight: 23.63 KDa
Source organism: Mus musculus
Structure domains: Immunoglobulins
PEPTIDE B1 Chains: E, F
Molecule details ›
Chains: E, F
Length: 12 amino acids
Theoretical weight: 1.62 KDa

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-4
Spacegroup: P21
Unit cell:
a: 66.88Å b: 69.53Å c: 110.19Å
α: 90° β: 97.71° γ: 90°
R-values:
R R work R free
0.198 0.197 0.245

Quick links

Citations

2 review citations

Antibody recognition of carbohydrate epitopes†.
Haji-Ghassemi et al. (2015)
1 more

2 mentions without citation

OptMAVEn--a new framework for the de novo design of antibody variable region models targeting specific antigen epitopes.
Li et al. (2014)
1 more