› 3gf9

X-ray diffraction
2.5Å resolution

Crystal structure of human Intersectin 2 RhoGEF domain

Released:
DOI: 10.2210/pdb3gf9/pdb
PDB entry 3gf9 coloured by chain, front view.
PDB entry 3gf9 coloured by chain, side view.
PDB entry 3gf9 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Shen Y, Tong Y, Tempel W, Li Y, Arrowsmith CH, Edwards AM, Bountra C, Weigelt J, Bochkarev A, Park H, Structural Genomics Consortium (SGC)

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-192766 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Intersectin-2 Chain: A
Molecule details ›
Chain: A
Length: 295 amino acids
Theoretical weight: 34.02 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9NZM3 (Residues: 1130-1406; Coverage: 16%)
Gene names: ITSN2, KIAA1256, SH3D1B, SWAP
Sequence domains:
Structure domains: Dbl homology (DH) domain

Ligands and Environments

1 bound ligand:
Ligand UNX 5 x UNX
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: C2
Unit cell:
a: 106.249Å b: 29.616Å c: 86.15Å
α: 90° β: 121.06° γ: 90°
R-values:
R R work R free
0.224 0.221 0.277
Expression system: Escherichia coli

Quick links