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Toluene 4-monooxygenase HD T201A diferric, resting state complex

Source organism: Pseudomonas mendocina
Biochemical function: monooxygenase activity
Biological process: toluene catabolic process
Cellular component: not assigned

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EC 1.14.13.236: Toluene 4-monooxygenase

Reaction catalysed:
Toluene + NADH + O(2) = 4-methylphenol + NAD(+) + H(2)O
Systematic name:
Toluene,NADH:oxygen oxidoreductase (4-hydroxylating)
Alternative Name(s):
  • TMO

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence families

Pfam Protein families (Pfam)
PF02332
Domain description: Methane/Phenol/Alkene Hydroxylase
Occurring in:
  1. Toluene-4-monooxygenase system, hydroxylase component subunit alpha
  2. Toluene-4-monooxygenase system, hydroxylase component subunit beta
The deposited structure of PDB entry 3ge8 contains 2 copies of Pfam domain PF02332 (Methane/Phenol/Toluene Hydroxylase) in Toluene-4-monooxygenase system, hydroxylase component subunit alpha. Showing 1 copy in chain A.
The deposited structure of PDB entry 3ge8 contains 2 copies of Pfam domain PF02332 (Methane/Phenol/Toluene Hydroxylase) in Toluene-4-monooxygenase system, hydroxylase component subunit beta. Showing 1 copy in chain B.

PF02406
Domain description: MmoB/DmpM family
Occurring in:
  1. Toluene-4-monooxygenase system, effector component
The deposited structure of PDB entry 3ge8 contains 2 copies of Pfam domain PF02406 (MmoB/DmpM family) in Toluene-4-monooxygenase system, effector component. Showing 1 copy in chain D [auth E].

PF06234
Domain description: Toluene-4-monooxygenase system protein B (TmoB)
Occurring in:
  1. Toluene-4-monooxygenase system, hydroxylase component subunit gamma
The deposited structure of PDB entry 3ge8 contains 2 copies of Pfam domain PF06234 (Toluene-4-monooxygenase system protein B (TmoB)) in Toluene-4-monooxygenase system, hydroxylase component subunit gamma. Showing 1 copy in chain C.

InterPro InterPro annotations
IPR036889
Domain description: Monooxygenase component MmoB/DmpM superfamily
Occurring in:
  1. Toluene-4-monooxygenase system, effector component
IPR036713
Domain description: TmoB-like superfamily
Occurring in:
  1. Toluene-4-monooxygenase system, hydroxylase component subunit gamma
IPR012078
Domain description: Methane/phenol monooxygenase, hydroxylase component
Occurring in:
  1. Toluene-4-monooxygenase system, hydroxylase component subunit beta
IPR003430
Domain description: Propane/methane/phenol/toluene hydroxylase
Occurring in:
  1. Toluene-4-monooxygenase system, hydroxylase component subunit alpha
  2. Toluene-4-monooxygenase system, hydroxylase component subunit beta
IPR009078
Domain description: Ferritin-like superfamily
Occurring in:
  1. Toluene-4-monooxygenase system, hydroxylase component subunit alpha
  2. Toluene-4-monooxygenase system, hydroxylase component subunit beta
IPR012348
Domain description: Ribonucleotide reductase-like
Occurring in:
  1. Toluene-4-monooxygenase system, hydroxylase component subunit alpha
  2. Toluene-4-monooxygenase system, hydroxylase component subunit beta
IPR003454
Domain description: Monooxygenase component MmoB/DmpM
Occurring in:
  1. Toluene-4-monooxygenase system, effector component
IPR009355
Domain description: Toluene-4-monooxygenase system B
Occurring in:
  1. Toluene-4-monooxygenase system, hydroxylase component subunit gamma

Structure domains

CATH CATH domains
1.10.620.20
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Ribonucleotide Reductase, subunit A
Homology: Ribonucleotide Reductase, subunit A
Occurring in:
  1. Toluene-4-monooxygenase system, hydroxylase component subunit alpha
  2. Toluene-4-monooxygenase system, hydroxylase component subunit beta
The deposited structure of PDB entry 3ge8 contains 2 copies of CATH domain 1.10.620.20 (Ribonucleotide Reductase, subunit A) in Toluene-4-monooxygenase system, hydroxylase component subunit alpha. Showing 1 copy in chain A.
The deposited structure of PDB entry 3ge8 contains 2 copies of CATH domain 1.10.620.20 (Ribonucleotide Reductase, subunit A) in Toluene-4-monooxygenase system, hydroxylase component subunit beta. Showing 1 copy in chain B.
3.90.56.10
Class: Alpha Beta
Architecture: Alpha-Beta Complex
Topology: Phenol Hydroxylase P2 Protein
Homology: Monooxygenase component MmoB/DmpM
Occurring in:
  1. Toluene-4-monooxygenase system, effector component
The deposited structure of PDB entry 3ge8 contains 2 copies of CATH domain 3.90.56.10 (Phenol Hydroxylase P2 Protein) in Toluene-4-monooxygenase system, effector component. Showing 1 copy in chain D [auth E].
3.10.20.270
Class: Alpha Beta
Architecture: Roll
Topology: Ubiquitin-like (UB roll)
Homology: TmoB-like
Occurring in:
  1. Toluene-4-monooxygenase system, hydroxylase component subunit gamma
The deposited structure of PDB entry 3ge8 contains 2 copies of CATH domain 3.10.20.270 (Ubiquitin-like (UB roll)) in Toluene-4-monooxygenase system, hydroxylase component subunit gamma. Showing 1 copy in chain C.

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