Function and Biology Details
Biochemical function:
Biological process:
Cellular component:
- not assigned
Sequence domains:
- EGF-like domain
- EGF-like calcium-binding domain
- Peptidase S8, subtilisin-related
- EGF-type aspartate/asparagine hydroxylation site
- Peptidase S8/S53 domain superfamily
- Peptidase S8 propeptide/proteinase inhibitor I9
- Peptidase S8 propeptide/proteinase inhibitor I9 superfamily
- EGF-like calcium-binding, conserved site
6 more domains
Structure analysis Details
Assembly composition:
hetero trimer (preferred)
Assembly name:
LDLR-PCSK9 complex (preferred)
PDBe Complex ID:
PDB-CPX-134047 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Proprotein convertase subtilisin/kexin type 9
Molecule details ›
Chain: P
Length: 100 amino acids
Theoretical weight: 11.28 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
Sequence domains: Peptidase inhibitor I9
Structure domains: Peptidase S8 propeptide/proteinase inhibitor I9
Length: 100 amino acids
Theoretical weight: 11.28 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
- Canonical:
Q8NBP7 (Residues: 53-152; Coverage: 15%)
Sequence domains: Peptidase inhibitor I9
Structure domains: Peptidase S8 propeptide/proteinase inhibitor I9
Proprotein convertase subtilisin/kexin type 9
Molecule details ›
Chain: A
Length: 540 amino acids
Theoretical weight: 57.44 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
Sequence domains:
Length: 540 amino acids
Theoretical weight: 57.44 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
- Canonical: Q8NBP7 (Residues: 153-692; Coverage: 82%)
Sequence domains:
- Subtilase family
- Proprotein convertase subtilisin-like/kexin type 9 C-terminal domain
- Proprotein convertase subtilisin-like/kexin type 9 C-terminal domain
- Proprotein convertase subtilisin-like/kexin type 9 C-terminal domain
Low-density lipoprotein receptor
Molecule details ›
Chain: E
Length: 83 amino acids
Theoretical weight: 9.12 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Structure domains: Laminin
Length: 83 amino acids
Theoretical weight: 9.12 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical: P01130 (Residues: 314-393; Coverage: 10%)
Structure domains: Laminin
