PDBe 3gci

X-ray diffraction
2.04Å resolution

Crystal Structure of the Complex Formed Between a New Isoform of Phospholipase A2 with C-terminal Amyloid Beta Heptapeptide at 2 A Resolution

Source organisms:
Entry authors: Mirza Z, Vikram G, Singh N, Sinha M, Bhushan A, Sharma S, Srinivasan A, Kaur P, Singh TP

Function and Biology Details

Reaction catalysed:
Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Acidic phospholipase A2 3 Chain: A
Molecule details ›
Chain: A
Length: 119 amino acids
Theoretical weight: 13.09 KDa
Source organism: Naja sagittifera
  • Canonical: P60045 (Residues: 8-126; Coverage: 94%)
Sequence domains: Phospholipase A2
Structure domains: Phospholipase A2 domain
P3(40) Chain: P
Molecule details ›
Chain: P
Length: 7 amino acids
Theoretical weight: 614 Da
Source organism: Homo sapiens
Expression system: Not provided
  • Canonical: P05067 (Residues: 707-713; Coverage: 1%)
Gene names: A4, AD1, APP

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU300
Spacegroup: P41
Unit cell:
a: 42.679Å b: 42.679Å c: 65.817Å
α: 90° β: 90° γ: 90°
R R work R free
0.19 0.184 0.221
Expression system: Not provided