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DNA binding site sequence directs glucocorticoid receptor structure and activity.

Meijsing SH, Pufall MA, So AY, Bates DL, Chen L, Yamamoto KR
Science 324 407-10 (2009)
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Cited: 431 times
EuropePMC logo PMID: 19372434

Abstract

Genes are not simply turned on or off, but instead their expression is fine-tuned to meet the needs of a cell. How genes are modulated so precisely is not well understood. The glucocorticoid receptor (GR) regulates target genes by associating with specific DNA binding sites, the sequences of which differ between genes. Traditionally, these binding sites have been viewed only as docking sites. Using structural, biochemical, and cell-based assays, we show that GR binding sequences, differing by as little as a single base pair, differentially affect GR conformation and regulatory activity. We therefore propose that DNA is a sequence-specific allosteric ligand of GR that tailors the activity of the receptor toward specific target genes.

Reviews - 3g6r mentioned but not cited (2)

  1. Roles of Prolyl Isomerases in RNA-Mediated Gene Expression. Thapar R. Biomolecules 5 974-999 (2015)
  2. The Biologist's Guide to the Glucocorticoid Receptor's Structure. Deploey N, Van Moortel L, Rogatsky I, Peelman F, De Bosscher K. Cells 12 1636 (2023)

Articles - 3g6r mentioned but not cited (2)

  1. Why does binding of proteins to DNA or proteins to proteins not necessarily spell function? Ma B, Tsai CJ, Pan Y, Nussinov R. ACS Chem Biol 5 265-272 (2010)
  2. Glucocorticoid resistance conferring mutation in the C-terminus of GR alters the receptor conformational dynamics. Kaziales A, Rührnößl F, Richter K. Sci Rep 11 12515 (2021)


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