3g2v

X-ray diffraction
2.1Å resolution

VHS Domain of human GGA1 complexed with Sotilin C-terminal Phosphopeptide

Released:
Source organism: Homo sapiens
Primary publication:
GGA autoinhibition revisited.
Traffic 11 259-73 (2010)
PMID: 20015111

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
ADP-ribosylation factor-binding protein GGA1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 149 amino acids
Theoretical weight: 16.96 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9UJY5 (Residues: 1-147; Coverage: 23%)
Gene name: GGA1
Sequence domains: VHS domain
Structure domains: Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat
Sortilin Chains: C, D
Molecule details ›
Chains: C, D
Length: 13 amino acids
Theoretical weight: 1.58 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q99523 (Residues: 819-831; Coverage: 2%)
Gene name: SORT1

Ligands and Environments

1 bound ligand:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-3
Spacegroup: P212121
Unit cell:
a: 48Å b: 72.9Å c: 102.5Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.206 0.204 0.244
Expression systems:
  • Escherichia coli
  • Not provided