X-ray diffraction
2Å resolution

VHS Domain of human GGA1 complexed with SorLA C-terminal Phosphopeptide

Source organism: Homo sapiens
Primary publication:
GGA autoinhibition revisited.
Traffic 11 259-73 (2010)
PMID: 20015111

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
ADP-ribosylation factor-binding protein GGA1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 149 amino acids
Theoretical weight: 16.96 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: Q9UJY5 (Residues: 1-147; Coverage: 23%)
Gene name: GGA1
Sequence domains: VHS domain
Structure domains: Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat
Sortilin-related receptor Chains: C, D
Molecule details ›
Chains: C, D
Length: 13 amino acids
Theoretical weight: 1.44 KDa
Source organism: Homo sapiens
Expression system: Not provided
  • Canonical: Q92673 (Residues: 2202-2214; Coverage: 1%)
Gene names: C11orf32, SORL1

Ligands and Environments

1 bound ligand:
1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-2
Spacegroup: P212121
Unit cell:
a: 55.8Å b: 68.3Å c: 100.6Å
α: 90° β: 90° γ: 90°
R R work R free
0.194 0.192 0.233
Expression systems:
  • Escherichia coli
  • Not provided