X-ray diffraction
2Å resolution

S437Y Mutant of human muscle pyruvate kinase, isoform M2

Source organism: Homo sapiens
Entry authors: Hong B, Dimov S, Allali-Hassani A, Tempel W, MacKenzie F, Arrowsmith CH, Edwards AM, Bountra c, Weigelt J, Bochkarev A, Vedadi M, Park H, Structural Genomics Consortium (SGC)

Function and Biology Details

Structure analysis Details

Assemblies composition:
homo tetramer
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Pyruvate kinase PKM Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 533 amino acids
Theoretical weight: 58.24 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: P14618 (Residues: 1-531; Coverage: 100%)
Gene names: OIP3, PK2, PK3, PKM, PKM2
Sequence domains:
Structure domains:

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: Rigaku FR-E
Spacegroup: P212121
Unit cell:
a: 105.546Å b: 137.885Å c: 155.684Å
α: 90° β: 90° γ: 90°
R R work R free
0.227 0.227 0.26
Expression system: Escherichia coli