X-ray diffraction
2.7Å resolution

Human dead-box RNA helicase DDX19, in complex with an ATP-analogue and RNA


Function and Biology Details

Reaction catalysed:
ATP + H(2)O = ADP + phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
1 distinct RNA molecule
Macromolecules (2 distinct):
ATP-dependent RNA helicase DDX19B Chain: A
Molecule details ›
Chain: A
Length: 424 amino acids
Theoretical weight: 48.03 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: Q9UMR2 (Residues: 54-475; Coverage: 88%)
Gene names: DBP5, DDX19, DDX19B, TDBP
Sequence domains:
Structure domains:
5'-R(P*UP*UP*UP*UP*UP*UP*U)-3' Chain: E
Molecule details ›
Chain: E
Length: 7 nucleotides
Theoretical weight: 2.1 KDa
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

3 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID29
Spacegroup: P212121
Unit cell:
a: 41.57Å b: 81.08Å c: 124.74Å
α: 90° β: 90° γ: 90°
R R work R free
0.22 0.217 0.275
Expression systems:
  • Escherichia coli
  • Not provided