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X-ray diffraction
2Å resolution

Crystal Structures of Hsc70/Bag1 in Complex with Small Molecule Inhibitors

Released:

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Heat shock cognate 71 kDa protein Chain: A
Molecule details ›
Chain: A
Length: 381 amino acids
Theoretical weight: 42.09 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P11142 (Residues: 4-381; Coverage: 59%)
Gene names: HSC70, HSP73, HSPA10, HSPA8
Structure domains:
BAG family molecular chaperone regulator 1 Chain: B
Molecule details ›
Chain: B
Length: 114 amino acids
Theoretical weight: 13.16 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q99933 (Residues: 222-334; Coverage: 33%)
Gene names: BAG1, HAP
Sequence domains: BAG domain
Structure domains: BAG domain

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RUH3R
Spacegroup: P21
Unit cell:
a: 40.576Å b: 120.827Å c: 53.519Å
α: 90° β: 106.62° γ: 90°
R-values:
R R work R free
0.218 0.214 0.272
Expression system: Escherichia coli