› 3fxt

X-ray diffraction
2.3Å resolution

Crystal structure of the N-terminal domain of human NUDT6

Released:
DOI: 10.2210/pdb3fxt/pdb
PDB entry 3fxt coloured by chain, front view.
PDB entry 3fxt coloured by chain, side view.
PDB entry 3fxt coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Tresaugues L, Welin M, Arrowsmith CH, Berglund H, Bountra C, Collins R, Dahlgren LG, Edwards AM, Flodin S, Flores A, Graslund S, Hammarstrom M, Johansson A, Johansson I, Karlberg T, Kotenyova T, Lehtio L, Moche M, Nilsson ME, Nyman T, Persson C, Sagemark J, Schueler H, Siponen MI, Thorsell AG, Van Den Berg S, Weigelt J, Wikstrom M, Nordlund P, Structural Genomics Consortium (SGC)

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156796 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Nucleoside diphosphate-linked moiety X motif 6 Chains: A, B, C, D, E, F, G, H
Molecule details ›
Chains: A, B, C, D, E, F, G, H
Length: 113 amino acids
Theoretical weight: 12.65 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P53370 (Residues: 45-134; Coverage: 29%)
Gene names: FGF2AS, NUDT6
Sequence domains: Nudix hydrolase domain
Structure domains: Aminopeptidase

Ligands and Environments

1 bound ligand:
Ligand GOL 6 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID29
Spacegroup: P6422
Unit cell:
a: 185.8Å b: 185.8Å c: 129.2Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.203 0.201 0.235
Expression system: Escherichia coli

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