3fvx

X-ray diffraction
1.5Å resolution

Human kynurenine aminotransferase I in complex with tris

Released:

Function and Biology Details

Reactions catalysed:
(1a) L-kynurenine + 2-oxoglutarate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate
(1a) an L-cysteine-S-conjugate = a thiol + 2-aminoporp-2-enoate
L-glutamine + phenylpyruvate = 2-oxoglutaramate + L-phenylalanine
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Kynurenine--oxoglutarate transaminase 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 422 amino acids
Theoretical weight: 48.16 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q16773 (Residues: 1-422; Coverage: 100%)
Gene names: CCBL1, KYAT1
Sequence domains: Aminotransferase class I and II
Structure domains:

Ligands and Environments

2 bound ligands:
1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X29A
Spacegroup: C2
Unit cell:
a: 102.881Å b: 107.439Å c: 81.686Å
α: 90° β: 112.87° γ: 90°
R-values:
R R work R free
0.18 0.178 0.2
Expression system: Spodoptera frugiperda