3fur

X-ray diffraction
2.3Å resolution

Crystal Structure of PPARg in complex with INT131

Released:

Function and Biology Details

Reaction catalysed:
Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine
Biochemical function:
Cellular component:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Peroxisome proliferator-activated receptor gamma Chain: A
Molecule details ›
Chain: A
Length: 272 amino acids
Theoretical weight: 31.09 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P37231 (Residues: 234-505; Coverage: 54%)
Gene names: NR1C3, PPARG
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor
Nuclear receptor coactivator 1 Chain: H
Molecule details ›
Chain: H
Length: 12 amino acids
Theoretical weight: 1.34 KDa
Source organism: synthetic construct
Expression system: Not provided
UniProt:
  • Canonical: Q15788 (Residues: 629-640; Coverage: 1%)
Gene names: BHLHE74, NCOA1, SRC1

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU300
Spacegroup: P212121
Unit cell:
a: 53.995Å b: 68.074Å c: 86.956Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.194 0.188 0.242
Expression systems:
  • Escherichia coli
  • Not provided