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Structure of HSP90 bound with a noval fragment.

X-ray diffraction
2Å resolution
PDB 3ft8 coloured by chain and viewed from the front.
PDB 3ft8 coloured by chain and viewed from the side.
PDB 3ft8 coloured by chain and viewed from the top.
Source organism: Homo sapiens
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Multimeric state: homo dimer
Accessible surface area: 18900 Å2
Buried surface area: 3100 Å2
Dissociation area: 750 Å2
Dissociation energy (ΔGdiss): 1 kcal/mol
Dissociation entropy (TΔSdiss): 13 kcal/mol
Interface energy (ΔGint): -17 kcal/mol
Symmetry number: 2

Macromolecules

Heat shock protein HSP 90-alpha
Chain: A
Length: 249 amino acids
Theoretical weight: 27.96 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P07900 (Residues: 9-236; Coverage: 31%)
Gene names: HSP90A, HSP90AA1, HSPC1, HSPCA
Pfam: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
InterPro:
CATH: Histidine kinase-like ATPase, C-terminal domain
PDB 3ft8 contains 2 copies of Heat shock protein HSP 90-alpha in assembly 1. This protein is highlighted and viewed from the front.
PDB 3ft8 contains 2 copies of Heat shock protein HSP 90-alpha in assembly 1. This protein is highlighted and viewed from the side.
PDB 3ft8 contains 2 copies of Heat shock protein HSP 90-alpha in assembly 1. This protein is highlighted and viewed from the top.
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