› 3fs3

X-ray diffraction
2.3Å resolution

Crystal structure of malaria parasite Nucleosome Assembly Protein (NAP)

Released:
DOI: 10.2210/pdb3fs3/pdb
PDB entry 3fs3 coloured by chain, front view.
PDB entry 3fs3 coloured by chain, side view.
PDB entry 3fs3 coloured by chain, top view.
Source organism: Plasmodium falciparum 3D7
Primary publication:
Crystal structure of malaria parasite nucleosome assembly protein: distinct modes of protein localization and histone recognition.
Gill J, Yogavel M, Kumar A, Belrhali H, Jain SK, Rug M, Brown M, Maier AG, Sharma A
J Biol Chem 284 10076-87 (2009)
PMID: 19176479

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-184698 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Nucleosome assembly protein Chain: A
Molecule details ›
Chain: A
Length: 359 amino acids
Theoretical weight: 42.05 KDa
Source organism: Plasmodium falciparum 3D7
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8I608 (Residues: 1-28, 29-347; Coverage: 100%)
Gene name: PF3D7_1203700
Sequence domains: Nucleosome assembly protein (NAP)
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE BM14
Spacegroup: C2
Unit cell:
a: 92.408Å b: 38.117Å c: 80.046Å
α: 90° β: 107.866° γ: 90°
R-values:
R R work R free
0.218 0.218 0.285
Expression system: Escherichia coli

Quick links

Citations

3 review citations

The histone shuffle: histone chaperones in an energetic dance.
Das et al. (2010)
2 more

6 mentions without citation

The Potential of Secondary Metabolites from Plants as Drugs or Leads against Protozoan Neglected Diseases-Part III: In-Silico Molecular Docking Investigations.
Ogungbe et al. (2016)
5 more