3fn0

X-ray diffraction
1.8Å resolution

Crystal structure of HIV-1 neutralizing human Fab Z13e1 in complex with a 12-residue peptide containing the Z13e1 epitope on gp41

Released:
Source organism: Homo sapiens
Entry authors: Pejchal R, Wilson IA, Zwick MB

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Fab Z13e1 Chain: L
Molecule details ›
Chain: L
Length: 212 amino acids
Theoretical weight: 23.1 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
Structure domains: Immunoglobulins
Fab Z13e1 Chain: H
Molecule details ›
Chain: H
Length: 231 amino acids
Theoretical weight: 24.75 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
Structure domains: Immunoglobulins
Envelope polyprotein gp160 Chain: P
Molecule details ›
Chain: P
Length: 9 amino acids
Theoretical weight: 1.22 KDa

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL11-1
Spacegroup: P41212
Unit cell:
a: 106.94Å b: 106.94Å c: 88.83Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.212 0.21 0.252
Expression system: Cricetulus griseus