› 3fl7

X-ray diffraction
2.5Å resolution

Crystal structure of the human ephrin A2 ectodomain

Released:
DOI: 10.2210/pdb3fl7/pdb
PDB entry 3fl7 coloured by chain, front view.
PDB entry 3fl7 coloured by chain, side view.
PDB entry 3fl7 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Architecture of Eph receptor clusters.
Himanen JP, Yermekbayeva L, Janes PW, Walker JR, Xu K, Atapattu L, Rajashankar KR, Mensinga A, Lackmann M, Nikolov DB, Dhe-Paganon S
Proc Natl Acad Sci U S A 107 10860-5 (2010)
PMID: 20505120

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
homo dimer
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151387 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ephrin type-A receptor 2 Chain: A
Molecule details ›
Chain: A
Length: 536 amino acids
Theoretical weight: 59.22 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P29317 (Residues: 23-531; Coverage: 53%)
Gene names: ECK, EPHA2
Sequence domains:
Structure domains:

Ligands and Environments

3 bound ligands:
Ligand NA 1 x NA
Ligand CL 3 x CL
Ligand NAG 1 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-B
Spacegroup: P21212
Unit cell:
a: 59.358Å b: 89.992Å c: 136.476Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.249 0.246 0.299
Expression system: Spodoptera frugiperda

Quick links

Citations

61 review citations

Mechanisms of ephrin-Eph signalling in development, physiology and disease.
Kania et al. (2016)
60 more

11 mentions without citation

Architecture of Eph receptor clusters.
Himanen et al. (2010)
10 more