› 3fko

X-ray diffraction
2Å resolution

P38 kinase crystal structure in complex with RO3668

Released:
DOI: 10.2210/pdb3fko/pdb
PDB 3fko coloured by chain and viewed from the front.
PDB 3fko coloured by chain and viewed from the side.
PDB 3fko coloured by chain and viewed from the top.
Source organism: Homo sapiens
Entry authors: Kuglstatter A, Knapp M

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mitogen-activated protein kinase 14 Chain: A
Molecule details ›
Chain: A
Length: 372 amino acids
Theoretical weight: 42.72 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q16539 (Residues: 1-360; Coverage: 100%)
Gene names: CSBP, CSBP1, CSBP2, CSPB1, MAPK14, MXI2, SAPK2A
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand FKO 1 x FKO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.2
Spacegroup: P212121
Unit cell:
a: 45.288Å b: 86.613Å c: 123.396Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.216 0.214 0.253
Expression system: Escherichia coli

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