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Crystal structure of JNK3 with indazole inhibitor, SR-3737

X-ray diffraction
2.2Å resolution
PDB entry 3fi3 coloured by chain, front view.
PDB entry 3fi3 coloured by chain, side view.
PDB entry 3fi3 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Mitogen-activated protein kinase 10
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Multimeric state: monomeric
Accessible surface area: 16458.17 Å2
Buried surface area: 406.7 Å2
Dissociation area: 109.56 Å2
Dissociation energy (ΔGdiss): -3.03 kcal/mol
Dissociation entropy (TΔSdiss): -0.29 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-156874

Macromolecules

Mitogen-activated protein kinase 10
Chain: A
Length: 364 amino acids
Theoretical weight: 42.24 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P53779 (Residues: 39-402; Coverage: 78%)
Gene names: JNK3, JNK3A, MAPK10, PRKM10, SAPK1B
Pfam: Protein kinase domain
InterPro:
CATH:
Mitogen-activated protein kinase 10 in PDB entry 3fi3, assembly 1, front view.
Mitogen-activated protein kinase 10 in PDB entry 3fi3, assembly 1, side view.
Mitogen-activated protein kinase 10 in PDB entry 3fi3, assembly 1, top view.
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