PDBe 3fer

X-ray diffraction
2.4Å resolution

Crystal structure of n-terminal actin-binding domain from human filamin b (tandem ch-domains). northeast structural genomics consortium target hr5571a.

Source organism: Homo sapiens
Entry authors: Kuzin AP, Abashidze M, Seetharaman R, Shastry R, Sahdev S, Ciccosanti C, Xiao R, Everett JK, Huang Y, Acton T, Rost B, Montelione GT, Tong L, Hunt JF, Northeast Structural Genomics Consortium (NESG)

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Filamin-B Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 262 amino acids
Theoretical weight: 30.54 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: O75369 (Residues: 1-252; Coverage: 10%)
Gene names: FLN1L, FLN3, FLNB, TABP, TAP
Sequence domains: Calponin homology (CH) domain
Structure domains: Calponin-like domain

Ligands and Environments

1 bound ligand:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4C
Spacegroup: C2
Unit cell:
a: 116.847Å b: 82.41Å c: 132.251Å
α: 90° β: 94.14° γ: 90°
R R work R free
0.215 0.215 0.259
Expression system: Escherichia coli