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Structure of headpiece of integrin aIIBb3 in open conformation

Source organism: Homo sapiens
Biochemical function: not assigned
Biological process: cell adhesion
Cellular component: integrin complex

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GO terms

Biochemical function:
  • not assigned
Biological process:
Cellular component:

Sequence families

Pfam Protein families (Pfam)
PF01839
Domain description: FG-GAP repeat
Occurring in:
  1. Integrin alpha-IIb heavy chain
The deposited structure of PDB entry 3fcu contains 6 copies of Pfam domain PF01839 (FG-GAP repeat) in Integrin alpha-IIb heavy chain. Showing 2 copies in chain A.

PF18372
Domain description: Integrin beta epidermal growth factor like domain 1
Occurring in:
  1. Integrin beta-3
The deposited structure of PDB entry 3fcu contains 3 copies of Pfam domain PF18372 (Integrin beta epidermal growth factor like domain 1) in Integrin beta-3. Showing 1 copy in chain B.

PF00362
Domain description: Integrin beta chain VWA domain
Occurring in:
  1. Integrin beta-3
The deposited structure of PDB entry 3fcu contains 3 copies of Pfam domain PF00362 (Integrin beta chain VWA domain) in Integrin beta-3. Showing 1 copy in chain B.

PF17205
Domain description: Integrin plexin domain
Occurring in:
  1. Integrin beta-3
The deposited structure of PDB entry 3fcu contains 3 copies of Pfam domain PF17205 (Integrin plexin domain) in Integrin beta-3. Showing 1 copy in chain B.

InterPro InterPro annotations
IPR015812
Domain description: Integrin beta subunit
Occurring in:
  1. Integrin beta-3
IPR013519
Domain description: Integrin alpha beta-propellor
Occurring in:
  1. Integrin alpha-IIb heavy chain
IPR000413
Domain description: Integrin alpha chain
Occurring in:
  1. Integrin alpha-IIb heavy chain
IPR036465
Domain description: von Willebrand factor A-like domain superfamily
Occurring in:
  1. Integrin beta-3
IPR002369
Domain description: Integrin beta subunit, VWA domain
Occurring in:
  1. Integrin beta-3
IPR013517
Domain description: FG-GAP repeat
Occurring in:
  1. Integrin alpha-IIb heavy chain
IPR028994
Domain description: Integrin alpha, N-terminal
Occurring in:
  1. Integrin alpha-IIb heavy chain
IPR040622
Domain description: Integrin beta, epidermal growth factor-like domain 1
Occurring in:
  1. Integrin beta-3
IPR032695
Domain description: Integrin domain superfamily
Occurring in:
  1. Integrin beta-3
IPR016201
Domain description: PSI domain
Occurring in:
  1. Integrin beta-3
IPR033760
Domain description: Integrin beta N-terminal
Occurring in:
  1. Integrin beta-3

Structure domains

CATH CATH domains
2.60.40.1510
Class: Mainly Beta
Architecture: Sandwich
Topology: Immunoglobulin-like
Homology: ntegrin, alpha v. Chain A, domain 3
Occurring in:
  1. Integrin beta-3
The deposited structure of PDB entry 3fcu contains 3 copies of CATH domain 2.60.40.1510 (Immunoglobulin-like) in Integrin beta-3. Showing 1 copy in chain B.
3.40.50.410
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: von Willebrand factor, type A domain
Occurring in:
  1. Integrin beta-3
The deposited structure of PDB entry 3fcu contains 3 copies of CATH domain 3.40.50.410 (Rossmann fold) in Integrin beta-3. Showing 1 copy in chain B.
3.30.1680.10
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: ligand-binding face of the semaphorins, domain 2
Homology: ligand-binding face of the semaphorins, domain 2
Occurring in:
  1. Integrin beta-3
The deposited structure of PDB entry 3fcu contains 3 copies of CATH domain 3.30.1680.10 (ligand-binding face of the semaphorins, domain 2) in Integrin beta-3. Showing 1 copy in chain B.
2.130.10.130
Class: Mainly Beta
Architecture: 7 Propeller
Topology: Methylamine Dehydrogenase; Chain H
Homology: Integrin alpha, N-terminal
Occurring in:
  1. Integrin alpha-IIb heavy chain
The deposited structure of PDB entry 3fcu contains 3 copies of CATH domain 2.130.10.130 (Methylamine Dehydrogenase; Chain H) in Integrin alpha-IIb heavy chain. Showing 1 copy in chain A.

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