› 3f74

X-ray diffraction
1.7Å resolution

Crystal structure of wild type LFA1 I domain

Released:
DOI: 10.2210/pdb3f74/pdb
PDB entry 3f74 coloured by chain, front view.
PDB entry 3f74 coloured by chain, side view.
PDB entry 3f74 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of isoflurane bound to integrin LFA-1 supports a unified mechanism of volatile anesthetic action in the immune and central nervous systems.
Zhang H, Astrof NS, Liu JH, Wang JH, Shimaoka M
FASEB J 23 2735-40 (2009)
PMID: 19332643

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-149031 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Integrin alpha-L Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 181 amino acids
Theoretical weight: 20.74 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P20701 (Residues: 153-332; Coverage: 16%)
Gene names: CD11A, ITGAL
Sequence domains: von Willebrand factor type A domain
Structure domains: von Willebrand factor, type A domain

Ligands and Environments

2 bound ligands:
Ligand GOL 2 x GOL
Ligand MG 1 x MG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P21
Unit cell:
a: 61.806Å b: 85.603Å c: 63.554Å
α: 90° β: 117.93° γ: 90°
R-values:
R R work R free
0.147 0.146 0.178
Expression system: Escherichia coli

Quick links

Citations

5 review citations

Integrins as therapeutic targets: lessons and opportunities.
Cox et al. (2010)
4 more

12 mentions without citation

Updates to the Integrated Protein-Protein Interaction Benchmarks: Docking Benchmark Version 5 and Affinity Benchmark Version 2.
Vreven et al. (2015)
11 more