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Crystal structure of the Vps10p domain of human sortilin/NTS3 in complex with neurotensin

X-ray diffraction
2Å resolution
PDB entry 3f6k coloured by chain, front view.
PDB entry 3f6k coloured by chain, side view.
PDB entry 3f6k coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Sortilin and Neurotensin
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Multimeric state: hetero dimer
Accessible surface area: 30955.96 Å2
Buried surface area: 2772.18 Å2
Dissociation area: 414.71 Å2
Dissociation energy (ΔGdiss): 3.55 kcal/mol
Dissociation entropy (TΔSdiss): 5.45 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-151867

Macromolecules

Sortilin
Chain: A
Length: 685 amino acids
Theoretical weight: 76.77 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: Q99523 (Residues: 78-756; Coverage: 85%)
Gene name: SORT1
Pfam:
InterPro:
CATH:
Sortilin in PDB entry 3f6k, assembly 1, front view.
Sortilin in PDB entry 3f6k, assembly 1, side view.
Sortilin in PDB entry 3f6k, assembly 1, top view.
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Neurotensin
Chain: N
Length: 13 amino acids
Theoretical weight: 1.68 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P30990 (Residues: 151-163; Coverage: 9%)
Gene name: NTS
Neurotensin in PDB entry 3f6k, assembly 1, front view.
Neurotensin in PDB entry 3f6k, assembly 1, side view.
Neurotensin in PDB entry 3f6k, assembly 1, top view.
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