X-ray diffraction
2Å resolution

Crystal structure of the Vps10p domain of human sortilin/NTS3 in complex with neurotensin


Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Sortilin Chain: A
Molecule details ›
Chain: A
Length: 685 amino acids
Theoretical weight: 76.77 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
  • Canonical: Q99523 (Residues: 78-756; Coverage: 85%)
Gene name: SORT1
Sequence domains:
Structure domains:
Neurotensin Chain: N
Molecule details ›
Chain: N
Length: 13 amino acids
Theoretical weight: 1.68 KDa
Source organism: Homo sapiens
Expression system: Not provided
  • Canonical: P30990 (Residues: 151-163; Coverage: 9%)
Gene name: NTS

Ligands and Environments

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: C2
Unit cell:
a: 145.76Å b: 74.53Å c: 108.33Å
α: 90° β: 131.87° γ: 90°
R R work R free
0.205 0.204 0.229
Expression systems:
  • Cricetulus griseus
  • Not provided