PDBe 3f66

X-ray diffraction
1.4Å resolution

Human c-Met Kinase in complex with quinoxaline inhibitor


Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Hepatocyte growth factor receptor Chains: A, B
Molecule details ›
Chains: A, B
Length: 298 amino acids
Theoretical weight: 33.85 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
  • Canonical: P08581 (Residues: 1052-1349; Coverage: 22%)
Gene name: MET
Sequence domains: Protein tyrosine kinase
Structure domains:

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P1
Unit cell:
a: 47.377Å b: 47.587Å c: 75.6Å
α: 100.7° β: 103.62° γ: 98.29°
R R work R free
0.168 0.168 0.225
Expression system: Spodoptera frugiperda