› 3f5n

X-ray diffraction
3.15Å resolution

Structure of native human neuroserpin

Released:
DOI: 10.2210/pdb3f5n/pdb
PDB entry 3f5n coloured by chain, front view.
PDB entry 3f5n coloured by chain, side view.
PDB entry 3f5n coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Human neuroserpin: structure and time-dependent inhibition.
Ricagno S, Caccia S, Sorrentino G, Antonini G, Bolognesi M
J Mol Biol 388 109-21 (2009)
PMID: 19265707

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-189224 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Neuroserpin Chains: A, B, C, D, E
Molecule details ›
Chains: A, B, C, D, E
Length: 407 amino acids
Theoretical weight: 46.32 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q99574 (Residues: 17-410; Coverage: 100%)
Gene names: PI12, SERPINI1
Sequence domains: Serpin (serine protease inhibitor)
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-2
Spacegroup: I222
Unit cell:
a: 171.796Å b: 179.176Å c: 248.263Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.237 0.234 0.283
Expression system: Escherichia coli

Quick links

Citations

9 review citations

Neonatal Hypoxia Ischaemia: Mechanisms, Models, and Therapeutic Challenges.
Millar et al. (2017)
8 more

13 mentions without citation

Neuroserpin: structure, function, physiology and pathology.
D'Acunto et al. (2021)
12 more