Structure analysis

Crystal structure and anti-tumor activity of LZ-8 from the fungus Ganoderma lucidium

X-ray diffraction
2.1Å resolution
Source organism: Ganoderma lucidum
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

Assemblies

Assembly 1 (preferred)
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Multimeric state: homo dimer
Accessible surface area: 11100 Å2
Buried surface area: 3000 Å2
Dissociation area: 1,500 Å2
Dissociation energy (ΔGdiss): 22 kcal/mol
Dissociation entropy (TΔSdiss): 12 kcal/mol
Interface energy (ΔGint): -29 kcal/mol
Symmetry number: 2

Macromolecules

Chains: A, B
Length: 111 amino acids
Theoretical weight: 12.52 KDa
Source organism: Ganoderma lucidum
Expression system: Komagataella pastoris
UniProt:
  • Canonical: P14945 (Residues: 1-111; Coverage: 100%)
Pfam: Fungal immunomodulatory protein Fve
InterPro:
CATH: Fungal immunomodulatory protein Fve

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