X-ray diffraction
1.8Å resolution

Crystal Structure of Human Haspin with an Imidazo-pyridazine ligand

Source organism: Homo sapiens
Entry authors: Filippakopoulos P, Eswaran J, Keates T, Burgess-Brown N, Fedorov O, Yue WW, Murray JW, Pike ACW, Von Delft F, Arrowsmith CH, Edwards AM, Weigelt J, Bountra C, Knapp S, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Serine/threonine-protein kinase haspin Chain: A
Molecule details ›
Chain: A
Length: 357 amino acids
Theoretical weight: 40.71 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: Q8TF76 (Residues: 465-798; Coverage: 42%)
Gene names: GSG2, HASPIN
Structure domains:

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P212121
Unit cell:
a: 72.416Å b: 77.307Å c: 85.575Å
α: 90° β: 90° γ: 90°
R R work R free
0.162 0.161 0.186
Expression system: Escherichia coli