Function and Biology

Structure of the transposase domain of human Histone-lysine N-methyltransferase SETMAR

Source organism: Homo sapiens
Biochemical function: nucleic acid binding
Biological process: not assigned
Cellular component: not assigned

EC 2.1.1.357: [Histone H3]-lysine(36) N-dimethyltransferase

Reaction catalysed:
(1a) S-adenosyl-L-methionine + a [histone H3]-L-lysine(36) = S-adenosyl-L-homocysteine + a [histone H3]-N(6)-methyl-L-lysine(36)
Systematic name:
S-adenosyl-L-methionine:[histone H3]-L-lysine(36) N(6)-dimethyltransferase

GO terms

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF01359
Domain description: Transposase (partial DDE domain)
Occurring in:
  1. Histone-lysine N-methyltransferase SETMAR
1 copy of Pfam domain PF01359 (Transposase (partial DDE domain)) in Histone-lysine N-methyltransferase SETMAR in PDB 3f2k.

InterPro InterPro annotation
IPR001888
Domain description: Transposase, type 1
Occurring in:
  1. Histone-lysine N-methyltransferase SETMAR

Structure domain

CATH CATH domain
3.30.420.10
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Nucleotidyltransferase; domain 5
Homology: Ribonuclease H-like superfamily/Ribonuclease H
Occurring in:
  1. Histone-lysine N-methyltransferase SETMAR
1 copy of CATH domain 3.30.420.10 (Nucleotidyltransferase; domain 5) in Histone-lysine N-methyltransferase SETMAR in PDB 3f2k.