Structure analysis

Structure of the transposase domain of human Histone-lysine N-methyltransferase SETMAR

X-ray diffraction
1.85Å resolution
Source organism: Homo sapiens
Assemblies composition:
hetero dimer (preferred)
monomeric
Entry contents: 2 distinct polypeptide molecules

Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero dimer
Accessible surface area: 10500 Å2
Buried surface area: 600 Å2
Dissociation area: 250 Å2
Dissociation energy (ΔGdiss): 1 kcal/mol
Dissociation entropy (TΔSdiss): 5 kcal/mol
Interface energy (ΔGint): -12 kcal/mol
Symmetry number: 1
Assembly 2
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Multimeric state: monomeric
Accessible surface area: 9800 Å2
Buried surface area: 100 Å2
Dissociation area: 50 Å2
Dissociation energy (ΔGdiss): 9 kcal/mol
Dissociation entropy (TΔSdiss): -1 kcal/mol
Interface energy (ΔGint): -7 kcal/mol
Symmetry number: 1

Macromolecules

Chains: A, B
Length: 226 amino acids
Theoretical weight: 26.78 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q53H47 (Residues: 459-684; Coverage: 33%)
Gene name: SETMAR
Pfam: Transposase (partial DDE domain)
InterPro: Transposase, type 1
CATH: Ribonuclease H-like superfamily/Ribonuclease H

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Chain: C
Length: 4 amino acids
Theoretical weight: 513 Da
Source organism: Homo sapiens
Expression system: Not provided

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