PDBe 3f22

X-ray diffraction
2.5Å resolution

Crystal structure of Zalpha in complex with d(CGTACG)


Function and Biology Details

Reaction catalysed:
Adenine in double-stranded RNA + H(2)O = hypoxanthine in double-stranded RNA + NH(3)
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Entry contents:
1 distinct polypeptide molecule
1 distinct DNA molecule
Macromolecules (2 distinct):
Double-stranded RNA-specific adenosine deaminase Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 81 amino acids
Theoretical weight: 9 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: P55265 (Residues: 133-209; Coverage: 6%)
Gene names: ADAR, ADAR1, DSRAD, G1P1, IFI4
Sequence domains: Adenosine deaminase z-alpha domain
Structure domains: Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain
DNA (5'-D(*DTP*DCP*DGP*DTP*DAP*DCP*DG)-3') Chains: D, E, F
Molecule details ›
Chains: D, E, F
Length: 7 nucleotides
Theoretical weight: 2.11 KDa
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL41XU
Spacegroup: P4212
Unit cell:
a: 85.937Å b: 85.937Å c: 71.201Å
α: 90° β: 90° γ: 90°
R R work R free
0.224 0.224 0.269
Expression systems:
  • Escherichia coli
  • Not provided