› 3f02

X-ray diffraction
1.8Å resolution

Cleaved human neuroserpin

Released:
DOI: 10.2210/pdb3f02/pdb
PDB entry 3f02 coloured by chain, front view.
PDB entry 3f02 coloured by chain, side view.
PDB entry 3f02 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Human neuroserpin: structure and time-dependent inhibition.
Ricagno S, Caccia S, Sorrentino G, Antonini G, Bolognesi M
J Mol Biol 388 109-21 (2009)
PMID: 19265707

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-189225 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Neuroserpin Chains: A, B
Molecule details ›
Chains: A, B
Length: 359 amino acids
Theoretical weight: 40.67 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q99574 (Residues: 17-362; Coverage: 88%)
Gene names: PI12, SERPINI1
Sequence domains: Serpin (serine protease inhibitor)
Structure domains:
Neuroserpin Chains: C, D
Molecule details ›
Chains: C, D
Length: 48 amino acids
Theoretical weight: 5.67 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q99574 (Residues: 363-410; Coverage: 12%)
Gene names: PI12, SERPINI1

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-1
Spacegroup: P21212
Unit cell:
a: 72.928Å b: 100.066Å c: 115.825Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.193 0.191 0.235
Expression system: Escherichia coli

Quick links

Citations

9 review citations

Neonatal Hypoxia Ischaemia: Mechanisms, Models, and Therapeutic Challenges.
Millar et al. (2017)
8 more

6 mentions without citation

Neuroserpin: structure, function, physiology and pathology.
D'Acunto et al. (2021)
5 more