› › Function and Biology

COMPLEX OF THE AMINO TERMINAL DOMAIN OF ENZYME I AND THE HISTIDINE-CONTAINING PHOSPHOCARRIER PROTEIN HPR FROM ESCHERICHIA COLI NMR, RESTRAINED REGULARIZED MEAN STRUCTURE

Source organism: Escherichia coli
Biochemical function: antisigma factor binding
Biological process: phosphoenolpyruvate-dependent sugar phosphotransferase system
Cellular component: cytosol

Quick links

EC 2.7.3.9: Phosphoenolpyruvate--protein phosphotransferase

Reaction catalysed:
Phosphoenolpyruvate + protein L-histidine = pyruvate + protein N(pi)-phospho-L-histidine
Systematic name:
Phosphoenolpyruvate:protein-L-histidine N(pi)-phosphotransferase
Alternative Name(s):
  • Enzyme I of the phosphotransferase system
  • Phosphoenolpyruvate sugar phosphotransferase enzyme I
  • Phosphoenolpyruvate--protein phosphatase
  • Phosphoenolpyruvate:protein-L-histidine N-pros-phosphotransferase
  • Phosphopyruvate--protein factor phosphotransferase
  • Phosphopyruvate--protein phosphotransferase
  • Sugar--PEP phosphotransferase enzyme I

GO terms

Sequence families

Pfam Protein families (Pfam)
PF00381
Domain description: PTS HPr component phosphorylation site
Occurring in:
  1. Phosphocarrier protein HPr
The deposited structure of PDB entry 3eze contains 1 copy of Pfam domain PF00381 (PTS HPr component phosphorylation site) in Phosphocarrier protein HPr. Showing 1 copy in chain B.

PF00391
Domain description: PEP-utilising enzyme, mobile domain
Occurring in:
  1. Phosphoenolpyruvate-protein phosphotransferase
The deposited structure of PDB entry 3eze contains 1 copy of Pfam domain PF00391 (PEP-utilising enzyme, mobile domain) in Phosphoenolpyruvate-protein phosphotransferase. Showing 1 copy in chain A.

PF05524
Domain description: PEP-utilising enzyme, N-terminal
Occurring in:
  1. Phosphoenolpyruvate-protein phosphotransferase
The deposited structure of PDB entry 3eze contains 1 copy of Pfam domain PF05524 (PEP-utilising enzyme, N-terminal) in Phosphoenolpyruvate-protein phosphotransferase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR000032
Domain description: Phosphocarrier protein HPr-like
Occurring in:
  1. Phosphocarrier protein HPr
IPR035895
Domain description: HPr-like superfamily
Occurring in:
  1. Phosphocarrier protein HPr
IPR036618
Domain description: PtsI, HPr-binding domain superfamily
Occurring in:
  1. Phosphoenolpyruvate-protein phosphotransferase
IPR002114
Domain description: Phosphotransferase system, HPr serine phosphorylation site
Occurring in:
  1. Phosphocarrier protein HPr
IPR001020
Domain description: Phosphotransferase system, HPr histidine phosphorylation site
Occurring in:
  1. Phosphocarrier protein HPr
IPR018274
Domain description: PEP-utilising enzyme, active site
Occurring in:
  1. Phosphoenolpyruvate-protein phosphotransferase
IPR008279
Domain description: PEP-utilising enzyme, mobile domain
Occurring in:
  1. Phosphoenolpyruvate-protein phosphotransferase
IPR036637
Domain description: Phosphohistidine domain superfamily
Occurring in:
  1. Phosphoenolpyruvate-protein phosphotransferase
IPR008731
Domain description: Phosphotransferase system, enzyme I N-terminal
Occurring in:
  1. Phosphoenolpyruvate-protein phosphotransferase
IPR006318
Domain description: Phosphotransferase system, enzyme I-like
Occurring in:
  1. Phosphoenolpyruvate-protein phosphotransferase

Structure domains

CATH CATH domains
3.50.30.10
Class: Alpha Beta
Architecture: 3-Layer(bba) Sandwich
Topology: Glucose Oxidase; domain 1
Homology: Phosphohistidine domain
Occurring in:
  1. Phosphoenolpyruvate-protein phosphotransferase
The deposited structure of PDB entry 3eze contains 1 copy of CATH domain 3.50.30.10 (Glucose Oxidase; domain 1) in Phosphoenolpyruvate-protein phosphotransferase. Showing 1 copy in chain A.
3.30.1340.10
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Histidine-containing Protein; Chain: A;
Homology: HPr-like
Occurring in:
  1. Phosphocarrier protein HPr
The deposited structure of PDB entry 3eze contains 1 copy of CATH domain 3.30.1340.10 (Histidine-containing Protein; Chain: A;) in Phosphocarrier protein HPr. Showing 1 copy in chain B.
1.10.274.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Enzyme I; Chain A, domain 2
Homology: PtsI, HPr-binding domain
Occurring in:
  1. Phosphoenolpyruvate-protein phosphotransferase
The deposited structure of PDB entry 3eze contains 1 copy of CATH domain 1.10.274.10 (Enzyme I; Chain A, domain 2) in Phosphoenolpyruvate-protein phosphotransferase. Showing 1 copy in chain A.
SCOP SCOP annotations
52013
Class: Alpha and beta proteins (a/b)
Fold: The "swivelling" beta/beta/alpha domain
Superfamily: Phosphohistidine domain
Occurring in:
  1. Phosphoenolpyruvate-protein phosphotransferase
The deposited structure of PDB entry 3eze contains 1 copy of SCOP domain 52013 (N-terminal domain of enzyme I of the PEP:sugar phosphotransferase system) in Phosphoenolpyruvate-protein phosphotransferase. Showing 1 copy in chain A.
55595
Class: Alpha and beta proteins (a+b)
Fold: HPr-like
Superfamily: HPr-like
Occurring in:
  1. Phosphocarrier protein HPr
The deposited structure of PDB entry 3eze contains 1 copy of SCOP domain 55595 (HPr-like) in Phosphocarrier protein HPr. Showing 1 copy in chain B.
47832
Class: All alpha proteins
Fold: SAM domain-like
Superfamily: Enzyme I of the PEP:sugar phosphotransferase system HPr-binding (sub)domain
Occurring in:
  1. Phosphoenolpyruvate-protein phosphotransferase
The deposited structure of PDB entry 3eze contains 1 copy of SCOP domain 47832 (Enzyme I of the PEP:sugar phosphotransferase system HPr-binding (sub)domain) in Phosphoenolpyruvate-protein phosphotransferase. Showing 1 copy in chain A.

Quick links