Function and Biology Details
Reaction catalysed:
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
Biochemical function:
- not assigned
Biological process:
- not assigned
Cellular component:
- not assigned
Sequence domains:
Structure analysis Details
Assembly composition:
monomeric (preferred)
Assembly name:
3C-like proteinase (preferred)
PDBe Complex ID:
PDB-CPX-143063 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Non-structural protein 3
Molecule details ›
Chain: A
Length: 168 amino acids
Theoretical weight: 18.35 KDa
Source organism: Human coronavirus 229E
Expression system: Escherichia coli
UniProt:
Sequence domains: Macro domain
Structure domains: Leucine Aminopeptidase, subunit E, domain 1
Length: 168 amino acids
Theoretical weight: 18.35 KDa
Source organism: Human coronavirus 229E
Expression system: Escherichia coli
UniProt:
- Canonical:
P0C6U2 (Residues: 1269-1436; Coverage: 4%)
Sequence domains: Macro domain
Structure domains: Leucine Aminopeptidase, subunit E, domain 1
Ligands and Environments
No bound ligands
No modified residues
Experiments and Validation Details
X-ray source:
PHOTON FACTORY BEAMLINE BL-5A
Spacegroup:
P212121
Expression system: Escherichia coli
