X-ray diffraction
2.6Å resolution

Crystal structure of the RhoGEF domain of human neuroepithelial cell-transforming gene 1 protein

Source organism: Homo sapiens
Entry authors: Nedyalkova L, Tong Y, Tempel W, MacKenzie F, Arrowsmith CH, Edwards AM, Bountra C, Weigelt J, Bochkarev A, Park H, Structural Genomics Consortium (SGC)

Function and Biology Details

Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Neuroepithelial cell-transforming gene 1 protein Chain: A
Molecule details ›
Chain: A
Length: 231 amino acids
Theoretical weight: 27.07 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: Q7Z628 (Residues: 161-373; Coverage: 36%)
Gene names: ARHGEF8, NET1
Structure domains: Dbl homology (DH) domain

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-D
Spacegroup: P64
Unit cell:
a: 95.629Å b: 95.629Å c: 62.887Å
α: 90° β: 90° γ: 120°
R R work R free
0.215 0.213 0.25
Expression system: Escherichia coli