X-ray diffraction
2.6Å resolution

The 2.6 A Crystal Structure of a Human A2A Adenosine Receptor bound to ZM241385.


Function and Biology Details

Reaction catalysed:
Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Adenosine receptor A2a; Endolysin Chain: A
Molecule details ›
Chain: A
Length: 488 amino acids
Theoretical weight: 54.74 KDa
Source organisms: Expression system: Spodoptera frugiperda
  • Canonical: P00720 (Residues: 2-161; Coverage: 98%)
  • Canonical: P29274 (Residues: 2-208, 222-316; Coverage: 73%)
Gene names: ADORA2, ADORA2A, E
Sequence domains:
Structure domains:

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-B
Spacegroup: P21
Unit cell:
a: 47.736Å b: 76.932Å c: 86.553Å
α: 90° β: 101.32° γ: 90°
R R work R free
0.198 0.196 0.231
Expression system: Spodoptera frugiperda