› 3ek1

X-ray diffraction
2.1Å resolution

Crystal structure of aldehyde dehydrogenase from brucella melitensis biovar abortus 2308

Released:
DOI: 10.2210/pdb3ek1/pdb
PDB entry 3ek1 coloured by chain, front view.
PDB entry 3ek1 coloured by chain, side view.
PDB entry 3ek1 coloured by chain, top view.
Source organism: Brucella abortus 2308
Entry author: Seattle Structural Genomics Center for Infectious Disease (SSGCID)

Function and Biology Details

Reaction catalysed: 
Succinate semialdehyde + NAD(P)(+) + H(2)O = succinate + NAD(P)H
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-174209 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Aldehyde dehydrogenase domain-containing protein Chains: A, B, C, D, E, F, G, H
Molecule details ›
Chains: A, B, C, D, E, F, G, H
Length: 504 amino acids
Theoretical weight: 53.61 KDa
Source organism: Brucella abortus 2308
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q2YRI3 (Residues: 1-483; Coverage: 100%)
Gene names: BAB1_1655, gabD
Sequence domains: Aldehyde dehydrogenase family
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand SO4 8 x SO4
Ligand MES 8 x MES
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.2
Spacegroup: P1
Unit cell:
a: 91.87Å b: 93.01Å c: 143.7Å
α: 92.03° β: 107.58° γ: 109.65°
R-values:
R R work R free
0.164 0.161 0.225
Expression system: Escherichia coli BL21(DE3)

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