› 3ebi

X-ray diffraction
2Å resolution

Structure of the M1 Alanylaminopeptidase from malaria complexed with the phosphinate dipeptide analog

Released:
DOI: 10.2210/pdb3ebi/pdb
PDB entry 3ebi coloured by chain, front view.
PDB entry 3ebi coloured by chain, side view.
PDB entry 3ebi coloured by chain, top view.
Source organism: Plasmodium falciparum FcB1/Columbia
Primary publication:
Structural basis for the inhibition of the essential Plasmodium falciparum M1 neutral aminopeptidase.
McGowan S, Porter CJ, Lowther J, Stack CM, Golding SJ, Skinner-Adams TS, Trenholme KR, Teuscher F, Donnelly SM, Grembecka J, Mucha A, Kafarski P, Degori R, Buckle AM, Gardiner DL, Whisstock JC, Dalton JP
Proc Natl Acad Sci U S A 106 2537-42 (2009)
PMID: 19196988

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-132164 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:

Ligands and Environments

4 bound ligands:
Ligand ZN 1 x ZN
Ligand BEY 1 x BEY
Ligand GOL 5 x GOL
Ligand MG 4 x MG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX1
Spacegroup: P212121
Unit cell:
a: 75.852Å b: 108.633Å c: 118.325Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.177 0.175 0.221
Expression system: Escherichia coli

Quick links

Citations

16 review citations

Plasmodium falciparum neutral aminopeptidases: new targets for anti-malarials.
Skinner-Adams et al. (2010)
15 more

7 mentions without citation

Marine Invertebrates: A Promissory Still Unexplored Source of Inhibitors of Biomedically Relevant Metallo Aminopeptidases Belonging to the M1 and M17 Families.
Pascual Alonso et al. (2023)
6 more