X-ray diffraction
2.5Å resolution

Human phosphoserine aminotransferase in complex with PLP

Source organism: Homo sapiens
Entry authors: Lehtio L, Karlberg T, Andersson J, Arrowsmith CH, Berglund H, Bountra C, Collins R, Dahlgren LG, Edwards AM, Flodin S, Flores A, Graslund S, Hammarstrom M, Johansson A, Johansson I, Kotenyova T, Moche M, Nilsson ME, Nordlund P, Nyman T, Olesen K, Persson C, Sagemark J, Thorsell SG, Tresaugues L, Van Den Berg S, Welin M, Wikstrom M, Wisniewska M, Weigelt J, Schueler H, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed:
4-phosphonooxy-L-threonine + 2-oxoglutarate = (3R)-3-hydroxy-2-oxo-4-phosphonooxybutanoate + L-glutamate
Biochemical function:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Phosphoserine aminotransferase Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 377 amino acids
Theoretical weight: 41.49 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: Q9Y617 (Residues: 17-370; Coverage: 96%)
Gene names: PSA, PSAT1
Structure domains:

Ligands and Environments

Cofactor: Ligand PLP 2 x PLP
1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID29
Spacegroup: P3121
Unit cell:
a: 171Å b: 171Å c: 103.88Å
α: 90° β: 90° γ: 120°
R R work R free
0.199 0.196 0.244
Expression system: Escherichia coli