› 3e3e

X-ray diffraction
2.01Å resolution

Human Thioredoxin Double Mutant C35S,C73R

Released:
DOI: 10.2210/pdb3e3e/pdb
PDB entry 3e3e coloured by chain, front view.
PDB entry 3e3e coloured by chain, side view.
PDB entry 3e3e coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of human thioredoxin exhibits a large conformational change.
Hall G, Emsley J
Protein Sci 19 1807-11 (2010)
PMID: 20661909

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145348 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Thioredoxin Chains: A, B
Molecule details ›
Chains: A, B
Length: 105 amino acids
Theoretical weight: 11.79 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P10599 (Residues: 1-105; Coverage: 100%)
Gene names: TRDX, TRX, TRX1, TXN
Sequence domains: Thioredoxin
Structure domains: Glutaredoxin

Ligands and Environments

1 bound ligand:
Ligand P6G 2 x P6G
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007
Spacegroup: P3221
Unit cell:
a: 62.05Å b: 62.05Å c: 90.61Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.214 0.209 0.261
Expression system: Escherichia coli

Quick links

Citations

5 review citations

The thioredoxin system as a therapeutic target in human health and disease.
Mahmood et al. (2013)
4 more

3 mentions without citation

Crystal structure of human thioredoxin revealing an unraveled helix and exposed S-nitrosation site.
Weichsel et al. (2010)
2 more