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Crystal structure of EcTrmB in complex with SAM

Source organism: Escherichia coli K-12
Biochemical function: tRNA (guanine(46)-N7)-methyltransferase activity
Biological process: tRNA modification
Cellular component: not assigned

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EC 2.1.1.33: tRNA (guanine(46)-N(7))-methyltransferase

Reaction catalysed:
S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA
Systematic name:
S-adenosyl-L-methionine:tRNA (guanine-N(7))-methyltransferase
Alternative Name(s):
  • 7-methylguanine transfer ribonucleate methylase
  • N(7)-methylguanine methylase
  • S-adenosyl-L-methionine:tRNA (guanine-7-N-)-methyltransferase
  • Transfer ribonucleate guanine 7-methyltransferase
  • Trm8/Trm82
  • TrmB
  • tRNA (m(7)G(46)) methyltransferase
  • tRNA (m7G46)-methyltransferase
  • tRNA guanine 7-methyltransferase

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF02390
Domain description: Putative methyltransferase
Occurring in:
  1. tRNA (guanine-N(7)-)-methyltransferase
The deposited structure of PDB entry 3dxy contains 1 copy of Pfam domain PF02390 (Putative methyltransferase ) in tRNA (guanine-N(7)-)-methyltransferase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR003358
Domain description: tRNA (guanine-N-7) methyltransferase, Trmb type
Occurring in:
  1. tRNA (guanine-N(7)-)-methyltransferase
IPR029063
Domain description: S-adenosyl-L-methionine-dependent methyltransferase superfamily
Occurring in:
  1. tRNA (guanine-N(7)-)-methyltransferase

Structure domain

CATH CATH domain
3.40.50.150
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: Vaccinia Virus protein VP39
Occurring in:
  1. tRNA (guanine-N(7)-)-methyltransferase
The deposited structure of PDB entry 3dxy contains 1 copy of CATH domain 3.40.50.150 (Rossmann fold) in tRNA (guanine-N(7)-)-methyltransferase. Showing 1 copy in chain A.

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