› 3dvi

X-ray diffraction
1.53Å resolution

Crystal structure of kappa 1 amyloidogenic light chain variable domain

Released:
DOI: 10.2210/pdb3dvi/pdb
PDB entry 3dvi coloured by chain, front view.
PDB entry 3dvi coloured by chain, side view.
PDB entry 3dvi coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural alterations within native amyloidogenic immunoglobulin light chains.
Randles EG, Thompson JR, Martin DJ, Ramirez-Alvarado M
J Mol Biol 389 199-210 (2009)
PMID: 19361523

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-213240 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Amyloidogenic light chain variable domain AL-103 Chain: A
Molecule details ›
Chain: A
Length: 109 amino acids
Theoretical weight: 11.97 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P41212
Unit cell:
a: 47.02Å b: 47.02Å c: 103.356Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.191 0.189 0.251
Expression system: Escherichia coli

Quick links

Citations

3 review citations

Immunoglobulin light chain amyloid aggregation.
Blancas-Mejia et al. (2018)
2 more

6 mentions without citation

Systemic amyloidoses.
Blancas-Mejía et al. (2013)
5 more