PDBe 3dt3

X-ray diffraction
2.4Å resolution

Human Estrogen receptor alpha LBD with GW368


Function and Biology Details

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Estrogen receptor Chains: A, B
Molecule details ›
Chains: A, B
Length: 255 amino acids
Theoretical weight: 29.12 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: P03372 (Residues: 299-551; Coverage: 43%)
  • Best match: P03372-2 (Residues: 254-439)
Gene names: ESR, ESR1, NR3A1
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: C2
Unit cell:
a: 103.309Å b: 57.996Å c: 88.331Å
α: 90° β: 105.15° γ: 90°
R R work R free
0.207 0.203 0.262
Expression system: Escherichia coli