› 3ds6

X-ray diffraction
2.9Å resolution

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172487 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mitogen-activated protein kinase 14 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 366 amino acids
Theoretical weight: 42 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q16539 (Residues: 1-360; Coverage: 100%)
Gene names: CSBP, CSBP1, CSBP2, CSPB1, MAPK14, MXI2, SAPK2A
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand A17 4 x A17
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E DW
Spacegroup: P212121
Unit cell:
a: 78.95Å b: 87.884Å c: 224.939Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.228 0.228 0.319
Expression system: Escherichia coli

Quick links

Citations

4 review citations

p38(MAPK): stress responses from molecular mechanisms to therapeutics.
Coulthard et al. (2009)
3 more

12 mentions without citation

The pyridazine heterocycle in molecular recognition and drug discovery.
Meanwell NA. (2023)
11 more