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Crystal structure of the guide-strand-containing Argonaute protein silencing complex

Source organism: Thermus thermophilus HB27
Biochemical function: metal ion binding
Biological process: clearance of foreign intracellular DNA
Cellular component: not assigned

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GO terms

Sequence families

Pfam Protein families (Pfam)
PF02171
Domain description: Piwi domain
Occurring in:
  1. Protein argonaute
The deposited structure of PDB entry 3dlh contains 2 copies of Pfam domain PF02171 (Piwi domain) in Protein argonaute. Showing 1 copy in chain A.

PF18309
Domain description: Argonaute PAZ domain
Occurring in:
  1. Protein argonaute
The deposited structure of PDB entry 3dlh contains 2 copies of Pfam domain PF18309 (Argonaute PAZ domain) in Protein argonaute. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR003165
Domain description: Piwi domain
Occurring in:
  1. Protein argonaute
IPR036397
Domain description: Ribonuclease H superfamily
Occurring in:
  1. Protein argonaute
IPR012337
Domain description: Ribonuclease H-like superfamily
Occurring in:
  1. Protein argonaute
IPR040895
Domain description: Argonaute, PAZ domain
Occurring in:
  1. Protein argonaute

Structure domains

CATH CATH domains
3.30.530.60
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Alpha-D-Glucose-1,6-Bisphosphate; Chain A, domain 4
Homology: Alpha-D-Glucose-1,6-Bisphosphate; Chain A, domain 4
Occurring in:
  1. Protein argonaute
The deposited structure of PDB entry 3dlh contains 2 copies of CATH domain 3.30.530.60 (Alpha-D-Glucose-1,6-Bisphosphate; Chain A, domain 4) in Protein argonaute. Showing 1 copy in chain A.
3.30.420.10
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Nucleotidyltransferase; domain 5
Homology: Ribonuclease H-like superfamily/Ribonuclease H
Occurring in:
  1. Protein argonaute
The deposited structure of PDB entry 3dlh contains 2 copies of CATH domain 3.30.420.10 (Nucleotidyltransferase; domain 5) in Protein argonaute. Showing 1 copy in chain A.
3.40.50.2300
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: Rossmann fold
Occurring in:
  1. Protein argonaute
The deposited structure of PDB entry 3dlh contains 2 copies of CATH domain 3.40.50.2300 (Rossmann fold) in Protein argonaute. Showing 1 copy in chain A.
2.170.260.50
Class: Mainly Beta
Architecture: Beta Complex
Topology: paz domain
Homology: paz domain
Occurring in:
  1. Protein argonaute
The deposited structure of PDB entry 3dlh contains 2 copies of CATH domain 2.170.260.50 (paz domain) in Protein argonaute. Showing 1 copy in chain A.
3.30.70.2620
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Alpha-Beta Plaits
Homology: Alpha-Beta Plaits
Occurring in:
  1. Protein argonaute
The deposited structure of PDB entry 3dlh contains 2 copies of CATH domain 3.30.70.2620 (Alpha-Beta Plaits) in Protein argonaute. Showing 1 copy in chain A.

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