X-ray diffraction
3.05Å resolution

Crystal structure of an activated (Thr->Asp) Polo-like kinase 1 (Plk1) catalytic domain in complex with Compound 094


Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Serine/threonine-protein kinase PLK Chain: A
Molecule details ›
Chain: A
Length: 317 amino acids
Theoretical weight: 35.99 KDa
Source organism: Danio rerio
Expression system: Escherichia coli
  • Canonical: Q4KMI8 (Residues: 1-312; Coverage: 52%)
Gene names: SO:0001217, cb525, cb636, ik:tdsubc_2d1, plk, plk1, wu:fb37g11, wu:fb76g03, xx:tdsubc_2d1
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL9-1
Spacegroup: I23
Unit cell:
a: 135.267Å b: 135.267Å c: 135.267Å
α: 90° β: 90° γ: 90°
R R work R free
0.252 0.25 0.276
Expression system: Escherichia coli