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A high resolution crystal structure of human glutamate carboxypeptidase II (GCPII) in a complex with DCIT, a urea-based inhibitor

Source organism: Homo sapiens
Biochemical function: tetrahydrofolyl-poly(glutamate) polymer binding
Biological process: C-terminal protein deglutamylation
Cellular component: extracellular exosome

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EC 3.4.17.21: Glutamate carboxypeptidase II

Reaction catalysed:
Release of an unsubstituted, C-terminal glutamyl residue, typically from Ac-Asp-Glu or folylpoly-gamma-glutamates.
Systematic name:
-
Alternative Name(s):
  • Acetylaspartylglutamate dipeptidase
  • Folate hydrolase
  • Folylpolyglutamate hydrolase
  • MGCP
  • Membrane glutamate carboxypeptidase
  • Microsomal gamma-glutamyl carboxypeptidase
  • N-acetylated alpha-linked acidic dipeptidase
  • N-acetylated-alpha-linked-amino dipeptidase
  • N-acetylated-gamma-linked-acidic dipeptidase
  • N-acetylated-gamma-linked-acidic dipeptidase (NAALADase)
  • NAALA dipeptidase
  • NAALADase
  • PSM antigen
  • PSMA
  • Prostate-specific membrane antigen
  • Prostrate-specific membrane antigen
  • Pteroylpoly-gamma-glutamate carboxypeptidase
  • Pteroylpoly-gamma-glutamate hydrolase
  • Pteroylpolygammaglutamyl hydrolase
  • Pteroylpolyglutamate hydrolase
  • Pteroylpolyglutamic acid hydrolase
  • Rat NAAG peptidase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF04253
Domain description: Transferrin receptor-like dimerisation domain
Occurring in:
  1. Glutamate carboxypeptidase 2
The deposited structure of PDB entry 3d7f contains 1 copy of Pfam domain PF04253 (Transferrin receptor-like dimerisation domain) in Glutamate carboxypeptidase 2. Showing 1 copy in chain A.

PF04389
Domain description: Peptidase family M28
Occurring in:
  1. Glutamate carboxypeptidase 2
The deposited structure of PDB entry 3d7f contains 1 copy of Pfam domain PF04389 (Peptidase family M28) in Glutamate carboxypeptidase 2. Showing 1 copy in chain A.

PF02225
Domain description: PA domain
Occurring in:
  1. Glutamate carboxypeptidase 2
The deposited structure of PDB entry 3d7f contains 1 copy of Pfam domain PF02225 (PA domain) in Glutamate carboxypeptidase 2. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR036757
Domain description: Transferrin receptor-like, dimerisation domain superfamily
Occurring in:
  1. Glutamate carboxypeptidase 2
IPR007365
Domain description: Transferrin receptor-like, dimerisation domain
Occurring in:
  1. Glutamate carboxypeptidase 2
IPR007484
Domain description: Peptidase M28
Occurring in:
  1. Glutamate carboxypeptidase 2
IPR003137
Domain description: PA domain
Occurring in:
  1. Glutamate carboxypeptidase 2
IPR046450
Domain description: PA domain superfamily
Occurring in:
  1. Glutamate carboxypeptidase 2
IPR039373
Domain description: Transferrin receptor protein 1/Glutamate carboxypeptidase 2-like
Occurring in:
  1. Glutamate carboxypeptidase 2

Structure domains

CATH CATH domains
3.40.630.10
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Aminopeptidase
Homology: Zn peptidases
Occurring in:
  1. Glutamate carboxypeptidase 2
The deposited structure of PDB entry 3d7f contains 1 copy of CATH domain 3.40.630.10 (Aminopeptidase) in Glutamate carboxypeptidase 2. Showing 1 copy in chain A.
1.20.930.40
Class: Mainly Alpha
Architecture: Up-down Bundle
Topology: Transcription Elongation Factor S-II; Chain A
Homology: Transferrin receptor-like, dimerisation domain
Occurring in:
  1. Glutamate carboxypeptidase 2
The deposited structure of PDB entry 3d7f contains 1 copy of CATH domain 1.20.930.40 (Transcription Elongation Factor S-II; Chain A) in Glutamate carboxypeptidase 2. Showing 1 copy in chain A.
3.50.30.30
Class: Alpha Beta
Architecture: 3-Layer(bba) Sandwich
Topology: Glucose Oxidase; domain 1
Homology: Glucose Oxidase; domain 1
Occurring in:
  1. Glutamate carboxypeptidase 2
The deposited structure of PDB entry 3d7f contains 1 copy of CATH domain 3.50.30.30 (Glucose Oxidase; domain 1) in Glutamate carboxypeptidase 2. Showing 1 copy in chain A.

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